Mechanisms of stable lipid loss in a social insect.

نویسندگان

  • Seth A Ament
  • Queenie W Chan
  • Marsha M Wheeler
  • Scott E Nixon
  • S Peir Johnson
  • Sandra L Rodriguez-Zas
  • Leonard J Foster
  • Gene E Robinson
چکیده

Worker honey bees undergo a socially regulated, highly stable lipid loss as part of their behavioral maturation. We used large-scale transcriptomic and proteomic experiments, physiological experiments and RNA interference to explore the mechanistic basis for this lipid loss. Lipid loss was associated with thousands of gene expression changes in abdominal fat bodies. Many of these genes were also regulated in young bees by nutrition during an initial period of lipid gain. Surprisingly, in older bees, which is when maximum lipid loss occurs, diet played less of a role in regulating fat body gene expression for components of evolutionarily conserved nutrition-related endocrine systems involving insulin and juvenile hormone signaling. By contrast, fat body gene expression in older bees was regulated more strongly by evolutionarily novel regulatory factors, queen mandibular pheromone (a honey bee-specific social signal) and vitellogenin (a conserved yolk protein that has evolved novel, maturation-related functions in the bee), independent of nutrition. These results demonstrate that conserved molecular pathways can be manipulated to achieve stable lipid loss through evolutionarily novel regulatory processes.

برای دانلود رایگان متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Comparison of six weeks of Iranian traditional medicine with modern medicine along with combined exercise on body weight loss and serum lipid profile in obese women

Objective Obesity is one of the problems of today's world and has become a global epidemic. The aim of this study was to compare the effect of 6 weeks of traditional Iranian medicine with modern medicine along with combined exercise on weight loss and serum lipid profile in obese women. Methods In this applied study, 24 obese women with a BMI above 30 were randomly divided into two groups of 1...

متن کامل

Recent developments in Pseudomonas biocontrol mechanisms

Fluorescent pseudomonads are an effective source of biological control that have high adaptive power and able to produce a wonderful source of secondary metabolites. Antibiotics such as phenazines, diacetylphloroglucinol, and hydrogen cyanide are produced by certain taxonomic groups of the genus Pseudomonas and appear to be ancestral. These compounds often play a physiological role in the produ...

متن کامل

From Separation to Loss of Identity: A Qualitative Explanation of Homelessness of Addicted People in Tehran

Introduction: The phenomenon of homelessness in the big cities of Iran, particularly in Tehran is a new subject as a serious social problem which was discussed in the public arena. The word "Homelessness", is mostly used for those who mainly spend nights in public spaces such as sidewalks, parks or under bridges. Therefore, in the literature of this problem, it is assumed that the homelessness ...

متن کامل

Combining Ability among Twenty Insect Resistant Maize inbred lines Resistant to Chilo partellus and Busseola fusca Stem borers

A partial diallel design was used among 20 maize inbred lines to form 110 F1 hybrids to generate information on the values of these lines for developing insect resistant maize varieties during the short rains season of 2006. The hybrids were evaluated for resistance to the C. partellus and B. fusca, and for agronomic performance over two seasons during long and short rains of 2007 at a mid-alti...

متن کامل

Does Serum lipid profile differ in anemia and non-anemic older subjects?

Background: There is some evidence that shows the symptoms of anemia are fewere in overweight and obese people, so, the purpose of this research was to study the relationship between anemia and iron deficiency anemia (IDA) with lipid profile status of the elderly. Methods: This cross-sectional study came from the Amirkola Health and Ageing Project (AHAP). A demographic questionnaire was given ...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

عنوان ژورنال:
  • The Journal of experimental biology

دوره 214 Pt 22  شماره 

صفحات  -

تاریخ انتشار 2011